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Oscar is a haughty saber-toothed cat, who only appeared in the first Ice Age film. He was part of the pack of tigers with Soto, Diego, Lenny and Zeke.

Mr. Tinkles is the main antagonist in the movie, Cats and Dogs

The Wu Sisters are three of the minor antagonists in Kung Fu Panda: The Game.

Ubasti is an evil cat and the true antagonist in Treasure Buddies. She is Wellington's hairless cat who is allergic to dogs.

Ubasti - Villains Wiki - villains, bad guys, comic books, anime

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This black cat is the main antagonist in the 1995 Australian animal film Napoleon

Puss in Boots or Puss' infamous cute face, which he uses on enemies so they won't attack.

Puss in Boots' greatest weapon.jpg

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Puss in Boots (or simply known as Puss) is the tritagonist in the Shrek

Black Cat is an anti-hero in the Spider-man comics.

Belome is a carnivorous, cat-like monster that appears as a recurring boss in Super Mario RPG: Legend of the Seven Stars. He is capable of creating evil clones of people by swallowing them and spitting them back out. He also likes to turn his victims into scarecrows when fighting them.

Tai Lung, a villain character from 2008 computer-animated feature film Kung Fu Panda. He was a snow leopard with supernatural Kung Fu abilities. His signature move was the nerve touch, where with one hit, he can paralyze his foe.

Tai Lung - Villains Wiki - villains, bad guys, comic books, anime

villains.wikia.com

Catbert, "evil director of human resources" from Dilbert comic strip

Apricot, Gilmore Girl series

Shere Khan from Disney's Jungle Book Movie (and character in book)

Simba, Disney The Lion King Movie

Snowball from The Simpsons animated television series

Si and Am Siamese cats from Disney movie, Lady and the Tramp

Si and Am Siamese cats from Disney's Lady and the Tramp movie

Zira from Disney's The Lion King movie

Mr. Bigglesworth, Dr. Evil's Cat in Austin Power movies

Kitty Galore, Dogs and Cats: Revenge of Kitty Galore movie

Tony the Tiger, Kellogg's Frosted Flakes Cereal commercials

Tonto from Harry and Tonto movie

Tom in Tom and Jerry cartoon