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Crohn's disease is a type of inflammatory bowel disease that can be incredibly challenging. In Crohn's disease, a rogue immune system attacks the digestive tract, causing inflammation and tissue damage. Symptoms include abdominal cramps, diarrhea, fever, & fatigue. Celebrities include Cynthia McFadden, Shannen Doherty, Dwight D. Eisenhower, and many others.

Living with multiple sclerosis can be even more challenging when you're a celebrity. Learn how the stars cope with this debilitating disease.

11 Female Celebrities with IBD and/or IBS Glad I'm not alone. It's not just a UGLY disease.

A look at famous people and celebrities with thyroid conditions including hypothyroidism, hyperthyroidism, Hashimoto's disease, Graves' disease, and nodules. Oprah Winfrey, Rod Stewart, Missy Elliot, Roger Ebert, Sofia Vergara, Tipper Gore, Kelly Osbourne, Kim Cattrall, Linda Ronstadt, Jillian Michaels.

Jack Osbourne didn't hide his multiple sclerosis while working towards the finale of "Dancing with the Stars." He's raised awareness of the debilitating disease. Learn about other celebrities raising awareness about important conditions.

Celebrities with Crohns disease battle Crohns symptoms in the public eye. Find out which celebrities are increasing awareness of Crohns.

Getting a Permanent Wave 1938 [for those 'Shirley Temple' curls]

Isaac W Sprague (1841-1887), Living Skeleton. He was normal until age 12, when he started to lose weight. By age 44 he was 5'6'' and weighed only 43 lbs. He was examined by many eminent physicians who gave no diagnosis other than a general wasting syndrome. He ate as much as 2 normal sized men and carried a flask of sweetened milk to revive himself when he felt faint. He married twice and had 3 average sized sons. He died at age 46 after working in sideshows since he was 24.

Guadalupe & Josephine Hinojosa, "The Cuban Twins", circa 1914. Sorry for the small scan size on this one.

Rhinoplasty. Loss of nose due to an injury, and replacement by a finger in 1880. Surgery by Dr. E. Hart, photo by OG Mason, both of Bellevue Hospital, NY.

Visiting Nurse Association St. Louis - 1935