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Catherine de Medici (1519 to 1589). Dauphine from 1536 to 1547, when she became queen. She was married to Henri II, but he neglected her for his mistress, Diane de Poitiers. She was rumored to have poisoned the Dauphin Francois, so that she and her husband could become king and queen.
Maria, Queen of Hungary, Niece of Catherine of Aragon She was born in Brussels to Philip I of Castile ("the Handsome") and Joanna "The Mad" of Castile. Her paternal grandparents were Maximilian I, Holy Roman Emperor and his first wife Mary of Burgundy. Her maternal grandparents were Ferdinand II of Aragon and Isabella of Castile.