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Edmund Tudor was Margaret Beaufort's second husband, and father of her only child, Henry. Henry became Henry VII, the first Tudor monarch, so you could say that Edmund was the grandfather of the dynasty. He was born around 1430, and died in 1456, as a prisoner of the Yorkists. He was supposed to wait a few years before consummating his marriage with his child bride, Margaret. He didn't, and Margaret was only 13 when Henry Tudor was born.

James V, King of Scotland, Son of Margaret Tudor, father of Mary, Queen of Scots, nephew of Henry VIII

Image from Vigiles de Charles VII by Martial d'Auvergne.

Isabella and Ferdinand with their daughter, Joanna, c. 1482. Image from "Rimado de la conquista de Granada", by Pedro Marcuello

Charles Howard, 1st Earl of Nottingham, maternal cousin of Anne Boleyn, Katheryn Howard, and Elizabeth I. Charles Howard, 1st Earl of Nottingham (1536 – 14 December 1624) was an English statesman and admiral. He was son of William Howard, 1st Baron Howard of Effingham (c. 1510 – 1573) and Margaret Gamage, daughter of Sir Thomas Gamage. He was a grandson of Thomas Howard, 2nd Duke of Norfolk. In June 1563 he married Catherine Carey, the oldest daughter of Henry Carey, 1st Baron Hunsdon.

King Henry VI (1422 - 1461) son of Henry V. He assumed royal power 1442 and sided with the party opposed to the continuation of the Hundred Years' War with France. After his marriage 1445, he was dominated by his wife, Margaret of Anjou. He was deposed 1461 in the Wars of the Roses; was captured 1465, temporarily restored 1470, but again imprisoned 1471 and then murdered. Henry was eight months old when he succeeded to the English throne.

An Indian woman, a Japanese woman, and a Syrian woman, all training to be doctors at Women’s Medical College of Philadelphia, 1880s. (Image courtesy Legacy Center, Drexel University College of Medicine Archives, Philadelphia, PA.

Margaret of Anjou, wife of Henry VI and Queen Consort. ca. XV.

February 8, 1487: Mary, Queen of Scots, executed. "I forgive you with all my heart, for now, I hope, you shall make an end to all my troubles," Mary told the executioner. His first blow missed her neck altogether. The second struck her neck, but didn't cut through -- he had to saw through to finish the job. When he held her head aloft by the hair, her wig came off and her head rolled to the ground. Then, a bloody little Skye terrier emerged from her skirts, and refused to leave his mistress.