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Rotavirus. Note the wheel-like appearance of some of the rotavirus particles. The observance of such particles gave the virus its name ('rota' being the Latin word meaning wheel). Bar = 100 nanometers. Rotaviruses are nonenveloped, double-shelled viruses, making the virus stable in the environment. Rotavirus is a virus that causes gastroenteritis (inflammation of the stomach and intestines).
Exploring HIV - Illustration by David S. Goodsell. If we can visualize a protein's shape, we can learn much more about how it functions and how we might block its activity. This was the guiding principle behind an NIH initiative launched 25 years ago to spur the discovery of HIV-related protein structures. Structures produced through the program have helped paint this detailed picture of the virus and have led to some important classes of drugs to treat the infection.