Guaifenesin INN or guaiphenesin (former BAN), also glyceryl guaiacolate, is an expectorant drug. Guaifenesin is thought to act as an expectorant by increasing the volume and reducing the viscosity of secretions in the trachea and bronchi. It also stimulates the flow of respiratory tract secretions, allowing ciliary movement to carry the loosened secretions upward toward the pharynx.
Ketamine is a drug used in human and veterinary medicine, primarily for the induction and maintenance of general anesthesia, usually in combination with a sedative. Pharmacologically, ketamine is classified as an NMDA receptor antagonist.
Dextromethorphan (DXM or DM) is an antitussive (cough suppressant) drug. It is one of the active ingredients in many over-the-counter cold and cough medicines, such as Mucinex DM, Robitussin, NyQuil, Dimetapp, Vicks, Coricidin, Delsym, TheraFlu, and others, including generic labels. Uncompetitive NMDA receptor (PCP site) antagonist (Ki = 7,253 nM).σ1 and σ2 sigma receptor agonist (Ki = 205 nM and 11,060 nM, respectively).
Bupropion (Wellbutrin, Zyban) is an atypical antidepressant and smoking cessation aid. Its chemical name is β-keto-3-chloro-N-tert-butylamphetamine, a substituted cathinone (β-ketoamphetamine), as well as substituted amphetamine. Its primary action is thought to be NE-DA reuptake inhibition. It binds selectively to the dopamine transporter, but its behavioural effects have often been attributed to its inhibition of NE reuptake. It also acts as a nicotinic ACh receptor antagonist.
Naltrexone (Vivitrol) is an opioid receptor antagonist for alcohol dependence and opioid dependence. It is marketed in generic form as its hydrochloride salt, naltrexone hydrochloride, and under the trade names Revia & Depade. In some countries including the United States, a once-monthly extended-release injectable formulation is the trade name Vivitrol. Also in the US, Methylnaltrexone Bromide, a closely related drug, is Relistor, for the treatment of opioid induced constipation.