Tranylcypromine (Parnate 10mg, Jatrosom) is a drug of the substituted phenethylamine and amphetamine classes which acts as a monoamine oxidase inhibitor (MAOI)—it is a nonselective and irreversible inhibitor of the enzyme monoamine oxidase (MAO). It is used as an antidepressant and anxiolytic agent in the clinical treatment of mood and anxiety disorders, respectively.
Bupropion (Wellbutrin, Zyban, Voxra, Budeprion, Prexaton, Elontril or Aplenzin ) is an atypical antidepressant and smoking cessation aid. It is a norepinephrine-dopamine reuptake inhibitor. It is also a nicotinic acetylcholine receptor antagonist. Treatment of Hypoactive Sexual Desire Disorder (HSDD) in women.
Dihydrotachysterol (DHT) is a synthetic vitamin D analog activated in the liver that does not require renal hydroxylation like vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). DHT has a rapid onset of action (2 hours), a shorter half-life, and a greater effect on mineralization of bone salts than does vitamin D
Canagliflozin (INN, trade name Invokana) is a drug for the treatment of type 2 diabetes. It was developed by Mitsubishi Tanabe Pharma and is marketed under license by Janssen, a division of Johnson & Johnson. Canagliflozin is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney.
The chemoreceptor trigger zone (CTZ) is an area of the medulla that receives inputs from blood-borne drugs, and communicates with the vomiting center to initiate vomiting. The CTZ is close to the area postrema on the floor of the fourth ventricle & is outside of the BBB. The neurotransmitters implicated in the control of nausea and vomiting include ACh, DA, histamine (H-1R), substance P, and 5-HT. The BBB is not as developed here, and drugs such as DA may stimulate the CTZ. ORs control the CTZ.
Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent developed by Bayer AG (initially called BAY 12-8039). It is marketed worldwide (as the hydrochloride) under the brand names Avelox, Avalox, and Avelon for oral treatment. In most countries, the drug is also available in parenteral form for intravenous infusion. Moxifloxacin is also sold in an ophthalmic solution (eye drops) under the brand names Vigamox, Moxeza for the treatment of conjunctivitis (pink eye).