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Phencyclidine (a complex clip of the chemical name 1-(1-phenylcyclohexyl)piperidine), (PCP) and known colloquially as angel dust or wet, is a recreational dissociative drug. Formerly used as an anesthetic agent, PCP exhibits both hallucinogenic and neurotoxic effects. PCP is an NMDA receptor antagonist.PCP is an NMDA receptor antagonist. PCP, like ketamine, also acts as a D2 receptor partial agonist. D2 receptor antagonists (such as haloperidol) can be used in the treatment of PCP psychosis.
NMDA receptor antagonists are a class of anesthetics that work to antagonize, or inhibit the action of, the N-methyl d-aspartate receptor (NMDAR). They are used as anesthesia for animals and, less commonly, for humans; the state of anesthesia they induce is referred to as dissociative anesthesia. Memantine is an uncompetitive NMDA channel blocker. Memantine is the first in a novel class of Alzheimer's disease medications acting on the glutamatergic system by blocking NMDA glutamate receptors.
Chlomethiazole acts as a positive allosteric modulator at the barbiturate/picrotoxin site of the GABA-A receptor. It works to enhance the action of the neurotransmitter GABA at this receptor. It is a drug which is structurally related to thiamine (vitamin B1) but acts like a sedative, hypnotic, muscle relaxant and anticonvulsant. Clomethiazole was the traditional treatment for delirium tremens, noe replaced by benzos.
Ipratropium bromide (INN, trade names Atrovent, Apovent, Ipraxa and Aerovent) is an anticholinergic drug used for the treatment of chronic obstructive pulmonary disease and acute asthma. It blocks the muscarinic acetylcholine receptors in the smooth muscles of the bronchi in the lungs, opening the bronchi.
Naloxone is an opioid inverse agonist drug developed by Sankyo in the 1960s.Naloxone is a drug used to counter the effects of opiate overdose, for example heroin or morphine overdose. It is marketed under various trademarks including Narcan, Nalone, and Narcanti.
Neuromuscular-blocking drugs block neuromuscular transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles. This is accomplished either by acting presynaptically via the inhibition of acetylcholine (ACh) synthesis or release or by acting postsynaptically at the acetylcholine receptors of the motor nerve end-plate. While some drugs act presynaptically (such as botulinum toxin and tetanus toxin), those of current clinical importance work postsynaptically.
Serotonin syndrome (serotonin toxicity) is a life-threatening consequence of excess serotonergic activity at CNS and peripheral serotonin receptors due to drugs. Treatment consists of discontinuing offending medications & administering a serotonin antagonist. An important adjunct treatment includes controlling agitation with benzodiazepine sedation. Libby Z. (Phenelzine & Demerol) died from serotonin syndrome & consequently changed graduate medical education in NYS. Serotonin pictured.