Epinephrine Auto-injectors (EAIs) -- EpiPen®, Auvi-Q™, Allerject™, generic epinephrine

This board answers many questions I have been asked about auto-injectors and how they work. I fired them, took them apart and did experiments on them in order to figure out how they worked and answer questions about them.
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FDA cleared and hopefully soon to be marketed, Vaccject is a combined syringe-cartridge product with an integrated retracting needle.  It could be an inexpensive alternative to auto-injectors and a safer and faster alternative to syringes and vials/ampules, for EMS systems and hospitals.  It might also provide an option for patients in nearly half the world where epinephrine auto-injectors are unavailable.

FDA cleared and hopefully soon to be marketed, Vaccject is a combined syringe-cartridge product with an integrated retracting needle. It could be an inexpensive alternative to auto-injectors and a safer and faster alternative to syringes and vials/ampules, for EMS systems and hospitals. It might also provide an option for patients in nearly half the world where epinephrine auto-injectors are unavailable.

A disassembled redesigned EpiPen.

Upgraded EpiPens torn apart. Tech firm: "It's the same core device"

A disassembled old-style EpiPen, prior to the 2009 redesign.

A disassembled old-style EpiPen, prior to the 2009 redesign.

Upgraded EpiPens torn apart. Tech firm: "It's the same core device"

Experts Tear Apart EpiPens, Hunting For Upgrades

One-caregiver options for immobilizing a child while administering an epinephrine auto-injector

One-caregiver options for immobilizing a child while administering an epinephrine auto-injector

EpiInject was a cool looking epinephrine auto-injector device.  It had a fund-raising campaign on Indiegogo at one point, then there has been no further word on the internet.

Epi Inject - Make It Easy To Administer Life Saving Treatment For Food Allergies Creating a new and easier type of treatment delivery system for a severe allergy attack.

Emerade is available in Europe in three strengths (0.15mg, 0.3 mg and 0.5mg).  Both pediatric and adult formulations have longer needles than other epinephrine auto-injectors with the same concentration of drug.

Emerade is available in Europe in three strengths mg and Both pediatric and adult formulations have longer needles than other epinephrine auto-injectors with the same concentration of drug.

A new, compact epinephrine auto-injector by Windgap is under development.  The epinephrine in this device will be stored as a powder, bringing hope for better temperature stability.

A new, compact epinephrine auto-injector by Windgap is under development. The epinephrine in this device will be stored as a powder, bringing hope for better temperature stability.

EpiPens were designed based on atropine injectors developed for the military.  The needles of these devices were intended to bend, so that they could be attached to a soldier's pocket as a way of keeping track of the doses of nerve gas antidote used.  Image from the Army Medical Manual Integrated Publishing.

EpiPens were designed based on atropine injectors developed for the military…

The EpiPen needle shown here fired slightly off-center.  This seems fairly common.  It may be due to how it compresses the rubber sterility barrier that protects the needle (shown in the bottom image, where the white needle shield is partially cut away).

The EpiPen needle shown here fired slightly off-center. This seems fairly common. It may be due to how it compresses the rubber sterility barrier that protects the needle (shown in the bottom image, where the white needle shield is partially cut away).

The Mylan generic appears to be identical to the Mylan EpiPen, except for minor differences in labeling.

Mylan's Generic vs Brand Epi Auto-Injector, the only difference is the label-the devices and medication are identical.

This clear-shelled Auvi-Q reveals the intelligent design inside.  The larger spring and attached pin (not visible) pierces the canister, releasing the argon gas that propels the needle (replaced by plastic in this model) and epinephrine.  When fully injected, release of the gas from the upper compartment allows the smaller spring to retract the needle, all in less than 2 seconds.

This clear-shelled Auvi-Q reveals the intelligent design inside. The larger spring and attached pin (not visible) pierces the canister, releasing the argon gas that propels the needle (replaced by plastic in this model) and epinephrine. When fully injected, release of the gas from the upper compartment allows the smaller spring to retract the needle, all in less than 2 seconds.

Epibracelet has a patent, but there's very little online information beyond that regarding progress towards production.

Epibracelet has a patent, but there's very little online information beyond that regarding progress towards production.

The Jext epinephrine auto-injector, available in England and other parts of Europe, is reminiscent of the old-style EpiPen.

I have a new Jext pen! i wouldn't recommend writing with it though.

A new compact epinephrine auto-injector called Oval is slated to expected to start appearing in European markets in 2018.

A new compact epinephrine auto-injector called Oval is slated to expected to start appearing in European markets in

In their Sept 8, 2016 letter to Congress, Mylan wrote: "This sterile injectable drug-in-device includes 26 separate parts".  For the EpiPen Jr, I count 19 including the drug and the label; 22 if I include the case and the clip between two cases. The EpiPen would have one fewer part, missing the little black circular piece that goes over the needle hub, effectively shortening the needle.

In their Sept 8, 2016 letter to Congress, Mylan wrote: "This sterile injectable drug-in-device includes 26 separate parts". For the EpiPen Jr, I count 19 including the drug and the label; 22 if I include the case and the clip between two cases. The EpiPen would have one fewer part, missing the little black circular piece that goes over the needle hub, effectively shortening the needle.

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