Neil Gaiman's series Sandman is know for its depth, rich literary references, and epic storyline. This series can be credited with bringing many women and readers outside the comics world to the format, and the richness of storytelling and mythology makes it easy to see why.
Ellis is always pretty much out to offend everyone, but as long as you know that going in, Transmetropolitan is one of the most entertaining, intelligent, and vicious takedowns of US politics, technology, and society yet to hit the comics stands. Not for the faint of heart.
If you loved the West Wing, Ex Machina might well be the series you've been looking for -- Mitchell Hundred decides he'll do much more good as Mayor of New York than masked superhero. When his past keeps coming back to haunt him, though, he begins to wonder if he made the right choice.
If you love superheroes mixed with procedural drama, look no further than this long-running series about Detective Christian Walker and his partner Deena Pilgrim trying to maintain law and order in a world full of superpowered folks on both sides of the law.
Another manga choice that defies expectations, this time the charming story of a young woman who travels to Rome to confront her wayward mother and ends up finding a job, a kind of family, and a new home.