Featured in Wizball, Pilot Wings 64, Sam & Max Hit the Road, and many more, the mighty Mount Rushmore has served game makers well.
In photos and real life the Eiffel Tower is epic and awesome. It's hard to imagine what a shocking sight of domineering industrial chic / gratuitousness it must have seemed when it was built in 1889.
Aloft in the mountains of Peru sits the amazing Machu Picchu.
"Stonehenge! 'Tis a magical place, where the moon doth rise with a dragon's face!" - once relatively abundant in games, thanks to the plethora of UK based game developers. Lyrics by Spinal Tap.
The whole awesome Giza Necropolis is the only survivor of the original Seven Wonders. I first remember seeing the Great Pyramid (plus Sphinx) as a background in Bomb Jack.
In the USA, down New Mexico way, there's a place called Lechuguilla Cave. As far as I'm aware it's never been used in a video game, although Superman clearly saw it before travelling back in time to build his nifty digs.
Sydney has two amazing landmarks - the striking Opera House and the big arching Harbour Bridge. Luckily they can both be seen in a single frame, so I don't have to choose between the two.
There must be loads of video games that have Mount Fuji in them, but I can't think of any. This is a classic shot with the blossom and bullet train in the foreground.