oh-soufflegirl: Hey everyone! Here (x) is my note on Genes (it includes Mitosis, Meiosis, and the Cell Life Cycle). If you’re having a hard time reading my handwriting, feel free to send an ask my way! I’ll try my best to respond to any questions as fast as possible. As always, I hope this note helps! Happy studying!
DNA Replication & Repair Remember!!! Inactivation of tumor suppresor genes fuck up DNA repair. Examples: p53: prevents damaged DNA to enter S phase. Deletion or Inactivation = LiFraumeni Sd. ATM gene: encodes a kinase for p53 activity. Inactive: Ataxia Telangectasia. BRCA-1: breast, prostate, ovarian cancer BRCA-2: breast cancer Rb gene: negative regulator, binds TF-E2f & repress transcription of genes required in S phase. Inactive or deletion = Retinoblastoma, Osteosarcoma.
In Greek, the word “macrophage” means “big eaters,” which is exactly what macrophages do. They are notably large cells whose job, as part of the innate immune response, is to engulf and digest cellular debris and invasive pathogens. They also stimulate other components of the immune system.
Phagocyte: engulfs microbes and uses lysosomes to digest them. Lysosomes fuse with the vacuole containing the microbes and release digestive enzymes like lysozymes & proteolytic enzyme. White blood cells are phagocytes that aid in immune response.
▶ Protein Synthesis Animation Video - 2:25 tRNA is joined to the mRNA by a peptide bond. A tRNA moved into the Asite where the codons match the mRNA the Ribosome shifts down by one codon at a time and new amino acids are added one at a time. It cuts off when a stop codon moves into the A site on the mRNA. The mRNA & the amino acid/protein are both released by the ribosome. p-site, A (acceptor) site & E site =Exit
Silent killer... Viewed this way is not scary, indeed it even has something artistic, but behind this innocent appearance hides a killer who kills every year millions of women: it is a cell of breast cancer under the microscope.