The chromosomal translocation characteristic of 70 percent of MCL(Mantel Cell Lymphoma) cases occurs between chromosomes 11 and 14 resulting in the overexpression of cyclinD1

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X-Chromosomal Translocation and Segmental Hypopigmentation — NEJM hypomelanosis of Ito

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Chromosomal translocation & associated neoplasms...

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BCR-ABL1 is a fusion gene formed as a result of the t(9;22)(q34;q11) chromosomal translocation, the translocation that results in the formation of the Philadelphia chromosome. The Abelson murine le...

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Janet Rowley - Discover of chromosomal translocations leading to disease. Did this at the University of Chicago while working part time and raising her family. Awarded Presidential Medal of Freedom by Barak Obama

In genetics, a chromosome translocation is a chromosome abnormality caused by rearrangement of parts between nonhomologous chromosomes

Scientists decipher the molecular basis of an as yet incurable leukemia in children - Although intensive research over the least decade has led to significant improvement of the survival rates of children suffering from ALL, a subset of patients still remains resistant to treatment. One such example is a very aggressive and incurable subtype associated with a t(17;19) chromosomal translocation, which occurs due to breakage and aberrant fusion of genetic material in the tumour cells…

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Ewing/PNET characteristic t(11;22) (q24;q12) leading to EWS-FLI1 fusion is encountered in 85% of Ewing Sarcoma/PNET cases. The majority of remaining cases (10-15%) demonstrate fusion of the EWS gene with a second member of the ETS family of genes, namely ERG. The EWS-ERG fusion occurs as a result of chromosomal translocation t(21;22)(q22;q12)

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