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Cyclin-dependent Kinase Cdk Inhibitors ( Methods in Molecular Biology) (Hardcover)

Here's the very "Circle of Life" right here The cycle of a cell's life, regulated by a specific set of proteins Cyclin-dependent kinase - Wikipedia, the free encyclopedia

Gossypin as a Novel Selective Dual Inhibitor of v-raf Murine Sarcoma Viral Oncogene Homolog B1 and Cyclin-Dependent Kinase 4 for Melanoma

5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5

In early M phase, SCFbeta-TRCP recognizes the phosphorylated APC/CCDC20 inhibitors EMI1 and EMI2, causing their degradation and an increase in APC/C activity. In late M phase, CDC20 is ubiquitylated, and therefore degraded, by APC/CCDH1 or by itself, leading to the transition from APC/CCDC20 to APC/CCDH1. CDH1 recognizes the D box of SKP2 and induces its degradation, resulting in low SCF complex activity and the accumulation of cyclin-dependent kinase inhibitors (CKIs) such as p27.