Vitamin B12 deficiency causes reversible megaloblastic anemia, demyelinating disease, or both. Current assays have insufficient sensitivity and specificity; methylmalonic acid levels are useful to confirm diagnosis. Parenteral or high-dose oral vitamin B12 is effective therapy.
Inflammatory Demyelinating Diseases (IDDs)-- sometimes called Idiopathic (IIDDs) because the unknown etiology of some of them, and sometimes known as borderline forms of multiple sclerosis, is a collection of multiple sclerosis variants, sometimes considered different diseases, but considered by others to form a spectrum differing only in terms of chronicity, severity, and clinical course.
Thyroid Dysfunction with Medication or Vaccine Induced Demyelinating Diseases "If you or your child are suffering with the constellation of symptoms associated with an inflammatory nerve disease such as multiple sclerosis and/or if you have known hypothyroid symptoms in combination with undiagnosed neuromuscular symptoms, it’s time to connect the dots...." www.thyroidchange.org
The story of the CSF PLoS One. 2016 Nov 17;11(11):e0166277. doi: 10.1371/journal.pone.0166277. eCollection 2016. Disease Type- and Status-Specific Alteration of CSF Metabolome Coordinated with Clinical Parameters in Inflammatory Demyelinating Diseases of CNS. Park SJ Jeong IH Kong BS Lee JE Kim KH Lee DY Kim HJ. Abstract Central nervous system (CNS) inflammatory demyelinating diseases (IDDs) are a group of disorders with different aetiologies characterized by inflammatory lesions. These…