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Anti-dsDNA. The anti-double stranded DNA (anti-dsDNA) test is used to help diagnose lupus (systemic lupus erythematosus, SLE) in a person who has a positive result on a test for antinuclear antibody (ANA) and has clinical signs and symptoms that suggest lupus.
Lupus is shorthand for a condition called systemic lupus erythematosus (SLE). Its an autoimmune disease that can take years to diagnose because of symptoms that can flare and subside, or masquerade as other illnesses.