Congenital hypertrophy of the retinal pigment epithelium (CHRPE) is usually found before patients reach 30 years of age. They may enlarge with time, but are not commonly associated with malignant transformation. There has been an association made between people with Gardner's Syndrome (familial colonic polyposes) and CHRPE.
osteoma What is the most common benign tumor of the nose and paranasal sinuses? Also associated with Gardner's Syndrome (image shows a sclerotic mass surrounded by air and located within the frontal sinus).
congenital hypertrophy of the retinal pigment epithelium (CHRPE) •Represents enlargement of RPE cells •Usually very dark clinically they are asymptomatic although careful plotting of the visual field may show absolute scotoma corresponding to the lesion. Patients with bilateral multiple lesions (bear tracking) may have Gardner's syndrome, FAP. More common temporally. Most CHRPE lesions also feature a pigmented or nonpigmented halo just inside the margin of the lesion
EPITHELIAL INCLUSION CYST Def: traumatic implantation of epidermis into dermis, plugged follicle Can be associated with Gardner's syndrome (polyposis) SSx: slow-growing, white, round, firm, usually < 1 cm DDx: neoplasm Tx: excision, marsupialization