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Exciting & Calming Your Brain: GABA & Glutamate in Fibromyalgia/ME/CFS

Glutamate can become what's called an "exitotoxin," meaning that it appears to excite neurons until they die, In FMS, research shows abnormally high levels of glutamate in a part of the brain called the insula or insular cortex. Researchers went looking there because that area is highly involved in pain and emotion, which are key components of the condition. In ME/CFS, some researchers hypothesize that glutamate function is low, which means the brain isn't getting enough stimulatio

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NMDA (N-methyl-D-aspartate) is the selective agonist that binds to NMDA receptors but not to other glutamate receptors. The NMDA receptor (NMDAR) is the predominant molecular device for controlling synaptic plasticity and memory function. The NMDAR is a type of ionotropic glutamate receptor. Activation of NMDA receptors requires binding of glutamate or aspartate (aspartate does not stimulate the receptors as strongly). In addition, NMDARs also require the binding of the co-agonist glycine.

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NMDA receptor antagonists are a class of anesthetics that work to antagonize, or inhibit the action of, the N-methyl d-aspartate receptor (NMDAR). They are used as anesthesia for animals and, less commonly, for humans; the state of anesthesia they induce is referred to as dissociative anesthesia. Memantine is an uncompetitive NMDA channel blocker. Memantine is the first in a novel class of Alzheimer's disease medications acting on the glutamatergic system by blocking NMDA glutamate…

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Thermodynamics and Mechanism of the Interaction of Willardiine Partial Agonists with a Glutamate Receptor: Implications for Drug Development

Activation of glutamate receptors, gives insights into the thinking http://www.sciencetotal.com/news/2016-07-activation-of-glutamate-receptors-gives-insights-into-the-thinking/

Cannabidiol (CBD), one of the chemical components found in marijuana, may have fast-acting antidepressant effects, according to a study published in Neurop ...

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Exercise during adolescence linked to lowered risk of death later

Exercise during adolescence linked to lowered risk of death later - http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/fitness/~3/oHHyWVPo7eI/150731070209.htm