Synapse. SEM of a neuromuscular junction showing a motor neuron (orange) terminating on skeletal muscle fibers (pink).

Synapse. SEM of a neuromuscular junction showing a motor neuron (orange) terminating on skeletal muscle fibers (pink).

Myasthenia Gravis. Myasthenia gravis (MG) was first described by Thomas Willis in 1672. It is an acquired autoimmune disease with antibodies against the nicotinic acetylcholine receptor (AChR) at the neuromuscular junction or muscle-specific tyrosine kinase (MuSK). This leads to muscular weakness with easy 'fatiguability', which is worse on exercise and improves with rest. (read more here)

Myasthenia Gravis. Myasthenia gravis (MG) was first described by Thomas Willis in 1672. It is an acquired autoimmune disease with antibodies against the nicotinic acetylcholine receptor (AChR) at the neuromuscular junction or muscle-specific tyrosine kinase (MuSK). This leads to muscular weakness with easy 'fatiguability', which is worse on exercise and improves with rest. (read more here)

Neuromuscular junction. The nerve (in white) transmits its signal to the skeletal muscle (grey tubes) to generate contraction.

Neuromuscular junction. The nerve (in white) transmits its signal to the skeletal muscle (grey tubes) to generate contraction.

Nerve and muscle thin section | 2013 Photomicrography Competition | Nikon Small World

Nerve and muscle thin section | 2013 Photomicrography Competition | Nikon Small World

This video discusses the concept of the neuromuscular junction. This is the beginning of muscular contraction (the excitation steps) where ACh (acetylcholine) is the neurotransmitter of muscle contraction.

This video discusses the concept of the neuromuscular junction. This is the beginning of muscular contraction (the excitation steps) where ACh (acetylcholine) is the neurotransmitter of muscle contraction.

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