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Vivitrol is an opiate antagonist that works by attaching to the brain’s opioid receptors and blocks the euphoric feelings associated with intoxication. Luckily, the drug does not block the brain from experiencing pleasure derived from other enjoyable activities. Vivitrol for opiate addiction drastically reduces cravings.

Non-specific opioid receptor antagonists (e.g., naloxone [Narcan, antidote for heroin overdose]) as well as the mixed opioid agonist/antagonist buprenorphine [Subutex, used to facilitate narcotics withdrawal] can be used to reverse the effects of kappa agonists.

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Opioids work by attaching to opioid receptors in the brain, dulling pain, stimulating the reward system in the brain, and increasing the production of the neurotransmitter dopamine which gives the user a euphoric feeling.

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Neonatal administration of thimerosal causes persistent changes in mu opioid receptors in the rat brain. (Neurochemical Research, November 2010)

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from Pain News Network

Quell Device Relieves Variety of Pain Conditions

Quell, from NeuroMetrix. Wearable pain relief. Transcutaneous electrical nerve stimulator device fits in band worn around upper calf. "Stimulates sensory nerves, which leads to the release of endogenous opioids that act primarily through the delta opioid receptor to reduce pain signal transmission through the CNS." For chronic pain associated with diabetes, fibromyalgia, sciatica, post herpatic neuralgia, chemotherapy-induced neuropathy, and other neuropathies. "FDA cleared prescription…

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Neonatal administration of thimerosal causes persistent changes in mu opioid receptors in the rat brain. (Neurochemical Research, November 2010)

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