The Air-Purifying Houseplant Soil: Pothos prefer a slightly acidic soil, but any well-draining potting mix will suffice. Water: Pothos like to have their soil dry out completely between waterings. If left continually in damp soil, the roots will rot. Let the plant tell you when to water. give them a splash of water whenever they start to droop. Don’t wait until the leaves start to shrivel or you will lose some leaves. Pothos is tolerant of low light conditions and erratic watering.