Tamoxifen induces remyelination Gonzalez GA Hofer MP Syed YA Amaral AI Rundle J Rahman S Zhao C Kotter MR. Tamoxifen accelerates the repair of demyelinated lesions in the central nervous system. Sci Rep. 2016;6:31599. Enhancing central nervous system (CNS) myelin regeneration is recognized as an important strategy to ameliorate the devastating consequences of demyelinating diseases such as multiple sclerosis. Previous findings have indicated that myelin proteins which accumulate following…
Credit: Paul Andrews, Univ. Dundee, Wellcome Images. Human HeLa cancer cells undergoing cytokinesis (cell division). The red fluorescence is the microtubules of the cytoskeleton. The white is actin. The blue is DNA (DAPI stain). The green is Aurora B, a protein kinase involved in the polymerisation/depolymerisation of the microtubules during mitosis and cytokinesis. The yellow area is the overlap between the red and the green fluorescence.
Berberine is found in Turmeric, Orgeon Grape, Barberry, Goldenseal. Berberine activates the stress response enzyme AMPK (activated AMP protein kinase). AMPK inhibits the body’s main growth pathway mTOR and thus counteract inflammation, fat gain, cholesterol buildup, cellular aging and formation of cancer cells.
The Handbook of Receptor Classification and Signal Transduction is a reference for scientists, researchers, educators, and the like. It contains over 100 entries covering such topics as Intracellular Signaling Enzymes and Receptors, signal transduction, Ion Channels, Non-Peptide Receptors, Synthesis and Metabolism, Peptide Receptors and Peptide Metabolism, Protein Kinase, Serine, Threonine, and Tyrosine Kinases, and Transporters.
P38 Signaling: Cellular responses to many external stimuli involve the activation of several types of MAPK (Mitogen-Activated Protein Kinase) signaling pathways. MAPKs are a family of Serine/threonine kinases that comprise 3 major subgroups, namely, ERK (Extracellular signal–Regulated Kinase), p38 MAPK and JNK (c-Jun N-terminal Kinases). Despite the diversity in function and upstream signaling events, MAPKs are.... http://www.sabiosciences.com/pathway.php?sn=P38_Signaling