Pausch learned that he had pancreatic cancer, a terminal illness, in September of 2006. He gave an upbeat lecture entitled "The Last Lecture: Really Achieving Your Childhood Dreams" on September 18, 2007 at Carnegie Mellon, which became a popular YouTube video
Randy Pausch: Really achieving your childhood dreams In 2007, Carnegie Mellon professor Randy Pausch, who was dying of pancreatic cancer, delivered a one-of-a-kind last lecture that made the world stop and pay attention. This moving talk will teach you how to really achieve your childhood dreams. Unmissable.