COSMIC: Catalogue Of Somatic Mutations In #Cancer. All cancers arise as a result of the acquisition of a series of fixed DNA sequence abnormalities, mutations, many of which ultimately confer a growth advantage upon the cells in which they have occurred. There is a vast amount of information available in the published scientific literature about these changes. COSMIC is designed to store and display somatic mutation information and related details and contains information relating to human…
This Trakehner colt, Holme Park Van Gogh, was an excellent example of a somatic mutation. The black patch on his otherwise bay coat was the result of the agouti gene misfiring leaving that section of his coat an undiluted black.
COSMIC (the Catalogue of Somatic Mutations in Cancer) is one of the most comprehensive global resources for information on somatic mutations in human cancer, combining curation of the scientific literature with tumor resequencing data from the Cancer Genome Project at the Sanger Institute, U.K. More here: http://www.ncbi.nlm.nih.gov/pubmed/20952405 and http://www.ncbi.nlm.nih.gov/pubmed/19906727
This is a mare whose odd white streaks are probably the result of a somatic mutation. Somatic mutations are the result of a gene that is accidentally switched "off," often resulting in odd patches of color on an otherwise ordinary coat.
Bay warmblood colt with somatic mutation by "Sometimes when an embryo is developing one of its skin cells undergoes a mutation. Any cell that is produced by this mutant cell dividing also contains the mutation. Cells originating from other layers of the gastrula, including sex cells, do not originate from the same layer as the skin cells and are not affected by a skin cell mutation. For this reason a dog which has a somatic mutation will not produce its dual color in offspring. "