Research suggests that some people with fibromyalgia may have elevated levels of substance P. This is believed to be one of several abnormalities in the nervous system that work together to increase pain sensitivity in the condition, a process that's often referred to as "turning up the volume" on pain. Substance P often functions as a neurotransmitter, which means that it communicates signals from one brain cell to another.
Extraordinary Homemade Hot Pepper Cream for Arthritis & Joint Pain. For all we know, the hot pepper contains capsaicin that reduces the amount of substance P. The substance P is a brain chemical that carries pain signals. So with less of it, you feel less pain.
This is called central sensitization. Every sense is heightened, and when it becomes overwhelming, it fires up our whole CNS and causes heightened pain. Once your CNS has been on alert 24/7 for years, you also develop more of substance P in the brain, the chemical that makes you feel pain. new scientific studies find that people with central sensitization have 5x as much substance P, making any pain we feel 5x stronger than normal people. Thanks for posting this!
RTPR-capsaicin Substance P is how your body tells your brain that you are experiencing pain. When you use topical products with high levels of menthol or take acetaminophen, aspirin and NSAIDs they are designed to simply mask your pain. The problem is the your body and brain recognize this and create more communicators (substance p) to make sure your brain gets the message.