Tissue holder out of a handkerchief - ridiculously easy! I wish I had seen this while Mom was still with us...she'd have loved it!
Shop Houzz: Traditional Powder Room Updates Under $250
Thankful turkey craft- could put things you are thankful for on papers into box, OR, use mason jar instead of tissue box and put change/money in for giving to needy. Or could use jar as candle holder.
TB8243-Plaid Tissue Box Cover / Marye-Kelley
This is a single sheet folded paper towel dispenser with a shelf for sale, but I bet you could replicate it as a DIY project with some crown molding and such and make it for a paper towel roll instead, if desired. Or a tissue box in the bathroom...
Fleur-de-Lis Tissue Box Cover
Tissue box holder based on a traditional tiger in Chinese culture.
Why have a plain kleenex box when you could make it beautiful?
Plastic Canvas - Holiday & Seasonal Patterns - Winter Patterns - Granny Squares Tissue Topper