You’d never suspect this by listening to pharmaceutical ads, but only one-third of people with major depression get better after trying an antidepressant. The others go on to try different drugs, or combinations of medicine and psychotherapy, and usually seven in 10 achieve remission. The other third? They are labeled with the three most dreaded

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Treatment resistant depression can often be misdiagnosed as Bipolar Disorder. Many people spend years trying various treatment options, only to get frustrated when nothing seems to work. The good news is there are effective treatment options.

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Understanding Treatment-Resistant Depression Don't give up if your depression treatment isn't helping you feel better. A change in your medication or a new approach might be the answer you need. Here are some of the many options. By Beth W. Orenstein Medically reviewed by Cynthia Haines, MD

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Ketamine, an anesthetic known as Special K, can work within hours to alleviate severe, treatment resistant, depression.

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