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Type 1: Plain old allergy (asthma, anaphylaxis, atopy) Type 2: Antibody-dependent, cytotoxic (think of autoimmune hemolytic anemia) Type 3: Immune complex disease (like a lot of the autoimmune conditions: rheumatoid, lupus) Type 4: Delayed/Cell-Mediated (mediated by T cells, T cells are slower to react than antibodies, so this reaction takes a couple days) Type 5: Receptor-mediated autoimmune disease (Graves, myasthenia gravis)

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Tuberculosis-primary infection; bacillus first enters body, macrophages engulf microbe causing local inflammatory response, some bacilli travel to lymph nodes (activate type IV hypersensitivity reaction); granuloma and tubercle forms, caseous necrosis and Ghon complexes develop, bacilli can remain dormant for years while remaining asymptomatic, but the person will test positive now.

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