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Inactivity and Metabolic Health
This is where I'm collecting and organizing information on the connection between inactivity and insulin resistance (and resultant metabolic dysfunction…
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habitual physical activity may prevent pathophysiological symptoms associated with diet-induced obesity.
habitual physical activity may prevent pathophysiological symptoms associated with diet-induced obesity.
Diet Plans To Lose Weight
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Obese Women
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Polycystic Ovary Syndrome
Two weeks of reduced activity decreases leg lean mass and induces ‘anabolic resistance’ of myofibrillar protein synthesis in healthy elderly
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Metabolism
Reduced
Interactive
Action
. One day of sitting considerably reduced insulin action;
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Fitness Training
Emerging evidence suggests that exercise stimulated endogenous opioid peptides influence diverse functions linked with the body's energy balance, including appetite, thermorégulation, lipolysis, and reproduction.
Metformin
Insulin Resistance
Liver Disease
Fatty Liver
Non Alcoholic
Diet with exercise seems to be superior to metformin and rosiglitazone.
Organ System
Benefits Of Exercise
Body Organs
Evidence
50 Years
Scientific
Abundant scientific evidence in the past 50 years has demonstrated the specific damage done to each of the body's organ systems by inactivity.
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the relative risks of type 2 diabetes were 16.75 (95% CI 13.99-20.04) for women who were obese (BMI ≥30 kg/m2) and inactive (exercise <2.1 MET h/week),10.74(8.74-13.18) for women who were active but obese, and 2.08 (1.66 -2.61) for women who were lean but inactive.
Placebo
Intervention
Diabetes
Confidence
The incidence of diabetes was 58 percent lower (95 percent confidence interval, 48 to 66 percent) in the lifestyle-intervention group and 31 percent lower (95 percent confidence interval, 17 to 43 percent) in the metformin group than in the placebo group.
Normal Weight Women
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Exercise And Mental Health
Physical Inactivity
Leptin
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Abdominal Obesity and Physical Inactivity as Risk Factors for NIDDM
Illinois
Risk
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Adiposity Compared With Physical Inactivity and Risk of Type 2 Diabetes in Women
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Nutrition Guide
Health And Nutrition
Beyond Diet
Daily Energy
Hdl Cholesterol
Life Challenges
Minimal Intensity Physical Activity (Standing and Walking) of Longer Duration Improves Insulin Action and Plasma Lipids More than Shorter Periods of Moderate to Vigorous Exercise (Cycling) in Sedentary Subjects When Energy Expenditure Is Comparable
Extracellular Fluid
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Negative energy balance plays a major role in the IGF-I response to exercise training
These results provide evidence that regularly performed, vigorous exercise can be effective in decreasing insulin resistance and improving glucose tolerance within 7 days in some patients with mild NIDDM.
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under physiologic conditions the extent of insulin secretion is not dependent only upon the blood glucose levels. The results show that a lack of insulin response can occur as a consequence of adaption to physical training.
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Skeletal Muscle
In Vivo
he data show that GLUT-4 is an insulin-responsive glucose transporter in skeletal muscle and, furthermore, that GLUT-4 also responds to acute exercise.
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Our results show that a rapid increase in GLUT4 expression is an early adaptive response of muscle to exercise.
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Level of physical exercise has been linked to improved glucose homeostasis and enhanced insulin sensitivity. Exercise training leads to alterations in expression and activity of key proteins involved in insulin signal transduction.
Demonstrate
Total Body
Nerdy
More than 85% of total body glucose metabolism during studies 1 and 3 was accounted for by skeletal muscle uptake. These results demonstrate that (a) insulin and exercise act synergistically to enhance glucose disposal
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The plasma insulin concentration during hyperglycemia was significantly lower after the exercise program.
Diabetes Treatment
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Sensitivity
An unchanged fasting glucose despite a reduced fasting insulin suggested exercise training improved insulin sensitivity.
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Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance
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Glucose Intolerance
Muscular Dystrophies
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Studies on the mechanism of improved glucose control during regular exercise in Type 2 (non-insulin-dependent) diabetes
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Metabolic flexibility: is there a way forward here to restoring tissue metabolic capacity? New work would suggest that the answer is quite possibly yes
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Modest Levels of Physical Activity Are Associated With a Lower Incidence of Diabetes in a Population With a High Rate of Obesity