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Early humans during the Ice Age hunted large mammals for the use of clothing, tools, and food. http://exhibits.museum.state.il.us/exhibits/larson/ice_age_animals.html
Extinct Arctodus simus roamed North America from Alaska to Florida during the Pleistocene: ~2.5 Mya until 12,000 years ago. The largest individuals are estimated to have weighed more than 2,500 lbs (1,200 kg).
