Mycetoma Sample for mycetoma Get a sample from the lesion. Can take a biopsy of the lesion. Definition of Mycetoma Mycetoma literally means fungal growth or maduromycosis of the foot. Mycetoma term refers to severe, deeply chronic, locally progressive, destructive, suppurative, and granulomatous disease. It begins in the subcutaneous tissue, usually of the hand and foot. This involves subcutaneous tissue, fascia, and bone. It is characterized by tumefaction, d...