▶ DNA Replication: The Cell's Extreme Team Sport - YouTube. Ever wonder how all the new cells in your body get a copy of your DNA? DNA replication is a very intricate and fascinating process you don't want to miss. In this video, we'll give a brief overview of DNA replication for eukaryote cells and introduce 4 key players: ligase, DNA polymerase, primase, and helicase. We'll also talk about why DNA can either run 5' to 3' or 3' to 5' by exploring the structure of DNA.