Margaret of Anjou (c.1429-82) was the daughter of Rene of Anjou & Isabella of Lorraine. Because of her vast inheritance, Margaret was a much sought-after bride. In 1444 she wed Henry VI of England by proxy. In 1445 she wed him in person aged 15. In 1453 her only child, Edward was born while her husband simultaneously suffered his 1st mental collapse. Margaret took over the government & got Henry to dissolve Parliament. She raised an army to overcome those who were threatening her power.
Arbella Stuart was a direct descendant of King Henry VII of England. As the only child of Charles Stuart, Earl of Lennox and Elizabeth Cavendish, she was a grandchild of Matthew Stewart, 4th Earl of Lennox and Margaret Douglas, who was, in turn, the daughter of Margaret Tudor, widow of James IV of Scotland, mother of James V of Scotland, and daughter of England's Henry VII. Margaret Douglas was the product of Margaret Tudor's second marriage, to Archibald Douglas, 6th Earl of Angus