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Ana de Mendoza y de la Cerda, Princesa de Eboli - a member of the Spanish Aristocracy in the 16th century. Despite having lost one of her eyes in a fencing accident as a teen, she was considered to be one of the most beautiful women in all of Spain.
Isabella I of Spain, well known as the patron of Christopher Columbus, with her husband Ferdinand II of Aragon, are responsible for making possible the unification of Spain under their grandson Carlos I. As part of the drive for unification, Isabella appointed Tomás de Torquemada as the first Inquisitor General of the inquisition. March 31, 1492 marks the implementation of the Alhambra Decree; expulsion edicts forcing the removal or conversion of Jews and Muslims. Roughly 200,000 people left
Elisabeth (isabella) of Valois, 1545-1568, eldest daughter of Henri II of France and his queen Catherine de' Medici. Married Philip II of Spain as his third wife at the age of 14. She had 2 surviving daughters, Isabella Clara Eugenia, Archduchess of Austria and Catherine Michelle Duchess of Savoy. Died in childbirth.