Soth Park (1997-) is chasing The Simpsons on ever lasting prouction of lessons of life. This is more anachistic, commenting on news and abosultion having nothing scared. You don't have to have photorealistic cartoon but you need a message.
South Park: I don't watch this show religiously by any means, but when I do I always enjoy it. Yes, the humor is crude and it's obvious the Trey Parker and Matt Stone have never heard the words political and correctness used together. However, that's exactly what makes the program so great. Beyond that IMO this is one of the most politically keen programs on television today.