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Are ladybugs poisonous? No. Ladybugs are not poisonous to humans. However, they can have toxic effects on some animals. Ladybugs have a foul odor which deters some predators from eating them and their bright colors also help as a deterrent. In nature, red and orange, are warning colors that indicate to another animal or insect that the potential "lunch item" might not be a good choice.