Aniscoria is having pupils of two different sizes. It can be genetic, a sign of a disease, or from an injury. David Bowie's permanently dilated pupil was caused by a punch to the eye. Judd Hirsch is another celebrity with this trait. Medical Science, Human Oddities, Judd Hirsch, Dilation Pupil, Permanent Dilation, Oddities Curiosity, Conditioning Characterization, David Bowie, Awesome Eye
Isaac W Sprague (1841-1887), Living Skeleton. He was normal until age 12, when he started to lose weight. By age 44 he was 5'6'' and weighed only 43 lbs. He was examined by many eminent physicians who gave no diagnosis other than a general wasting syndrome. He ate as much as 2 normal sized men and carried a flask of sweetened milk to revive himself when he felt faint. He married twice and had 3 average sized sons. He died at age 46 after working in sideshows since he was 24.
Rhinoplasty. Loss of nose due to an injury, and replacement by a finger in 1880. Surgery by Dr. E. Hart, photo by OG Mason, both of Bellevue Hospital, NY.