How to Remove Lipstick Stains How to Remove Lipstick Stains Got a lipstick stain on your shirt? Don’t fret, use this tip to get the stain out! Spray some hairspray on the stain and allow it to sit for 15 minutes. Dap the stain with a damp cloth, then wash the garment with laundry detergent and a bit of baking soda. Make sure the stain is gone before putting through the dryer!