The Dead Sea is 427 meters below sea level and is the lowest place on earth. The Dead Sea is 306 m (1,004 ft) deep, the deepest hypersaline lake in the world. With 34.2% salinity (in 2011), it is also one of the world’s saltiest bodies of water - Photo credit: Victor B
Dead Sea (Israel). 'Floating in the Dead Sea is one of the world’s great natural experiences. Thanks to an eye-stingingly high salt content it is virtually impossible to swim in the viscous waters of a sea that is 1000ft lower than sea level. The experience is usually accompanied by a mud bath, a bake in the sun and a health-giving spa treatment at one of the modern pleasure palaces lined up along the shores.' http://www.lonelyplanet.com/israel-and-the-palestinian-territories/dead-sea
The Jordan River (well, what's left of it), in the Middle East, is the lowest river in the world. It ends in the Dead Sea, at a depth of 1,312 feet (400 meters) below sea level. The river is important to Christians, Jews, and Muslims because of its location in an area that is holy to all three.