Animaniacs - Three cartoon characters that were locked up in the Warner Brothers Movie Lot's Water Tower since the 1930's, escape in the 1990's, and cause havoc/slapstick and mock Hollywood personalities. Other shows within this show existed as well, most notably Pinky and the Brain. They were two lab mice that secretly wanted to take over and control Earth.
Before Shia LeBeouf was a star, he was a pain in his older sister's pants (Christy Carlson Romano, "Kim Possible"). Also starring Nick Spano ("Gia") as the other brother, Tom Virtue ("Read It and Weep") as dad, and Donna Pescow ("Saturday Night Fever") as mom, a Sacramento legislator.