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The island was renamed Welfare Island in 1921, and in the 1950s many of the institutions on the island became obsolete and were abandoned.

Renwick Smallpox Hospital on Welfare Island; Renamed Roosevelt Island in 1973. Abandoned in 1962; preservation effort was attempted in 1975 but failed and the building was left to collapse and decay. (©2004

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Inside the lost island of New York: Eerie pictures of the abandoned leper colony just 350 yards from the Bronx

Interesting read about an abandoned institution in NYC