Claude Gouffier was married 5 times. His first wife was Jacqueline de la Tremoille who he wed en 1527. She attempted to murder him by poisoning, and was sentenced to prison and her confessor to death. She died in 1544. His next wife was Françoise de Brosse de Britain, who died in childbirth in 1558, and next was Mary Gaignon St-Bohaire who perished en 1565. In 1567 he married Claude de Beaune, who also died. His fifh marriage was in 1569 to Antoinette de la Tour-Landry.