TIP: Traveling with young kids made easy: Put an entire outfit (including undies and hair accessories) in a ziploc bag. One bag per day. When you get to the hotel, put the bags in a drawer and they can pick one per day. Huge time saver!
Put everything for one day (outfit, hair bow, pj) in a huge zip loc bag. Carry just that bag into the hotel instead of the massive suitcase. We did this for our 10 day trip in which we stayed in 9 different hotels. I used plastic grocery sacks labeled with city's name. Each bag had both kids outfits, pjs, and their pull ups.
My friend packed for a road trip...She has 5 children. Each ziploc has an outfit, undies, socks and is labeled with the childs name. This is genius! In this one bag there are 46 outfits, 15 pair of PJs, 10 sweatshirts, 21 pair of undies, 40 pair of socks! She is an amazing Mama!