The Synthesis Effect: Transform your Life with Dr. John McGrail! For far too many of us, modern life is a struggle. We are stressed, depressed, anxious, terrified and angry. Are we doomed to live this way? Dr. John McGrail answers with an emphatic: “No. Anyone and everyone can create the life of their dreams.” In his new book, The Synthesis Effect – Your Direct Path to Personal Power and Transformation, he shares and teaches his technique for creating profound personal change.