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  • Jessica Mandula

    Methoxetamine (MXE), or 3-MeO-2-Oxo-PCE is a dissociative anesthetic that has been sold as a designer drug.[1][2] Methoxetamine differs from many dissociatives such as ketamine and phencyclidine that were developed as pharmaceuticals in that it was designed for grey market distribution.[2][3] Pharmacologically, methoxetamine acts as a NMDA receptor antagonist. Unlike the related compound ketamine, MXE has appreciable affinity for the serotonin transporter.[4]

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