Methoxetamine (MXE) or 3-MeO-2-Oxo-PCE is a chemical of the arylcyclohexylamine class which has been sold as a designer drug.[1] It is a derivative of ketamine that also contains structural features of eticyclidine and 3-MeO-PCP. Methoxetamine is thought to behave as a NMDA receptor antagonist and dopamine reuptake inhibitor, though it has not been formally profiled pharmacologically.

Amantadine (Symmetrel) is a drug that has US Food and Drug Administration approval for use both as an antiviral and an antiparkinsonian drug.Amantadine is a weak antagonist of the NMDA type glutamate receptor, increases dopamine release, and blocks dopamine reuptake.Amantadine has been associated with several central nervous system (CNS) side effects, likely due to amantadine's dopaminergic and adrenergic activity, and to a lesser extent, its activity as an anticholinergic.

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Bupropion is a drug primarily used as an atypical antidepressant and smoking cessation aid. Marketed as Wellbutrin, Budeprion, Prexaton, Elontril, Aplenzin, or other trade names, it is one of the most frequently prescribed antidepressants in the United States. Marketed in lower-dose formulations as Zyban, Voxra, or other names, it is also widely used to reduce nicotine cravings by people who are trying to quit smoking. It is taken in the form of pills.

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Guaifenesin is thought to act as an expectorant by increasing the volume and reducing the viscosity of secretions in the trachea and bronchi.

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NMDA receptor antagonists are a class of anesthetics that work to antagonize, or inhibit the action of, the N-methyl d-aspartate receptor (NMDAR). They are used as anesthesia for animals and, less commonly, for humans; the state of anesthesia they induce is referred to as dissociative anesthesia. Memantine is an uncompetitive NMDA channel blocker. Memantine is the first in a novel class of Alzheimer's disease medications acting on the glutamatergic system by blocking NMDA glutamate receptors...

Methoxetamine or MXE commonly called Mexxy is a synthetic drug sold on the internet with similar effects to Ketamine

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A8; XLR111; 5FUR-144 (1-(5-fluoropentyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone (1-(5-fluoropentyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone Novel cannabinoid

Bupropion (Wellbutrin, Zyban, Voxra, Budeprion, Prexaton, Elontril or Aplenzin ) is an atypical antidepressant and smoking cessation aid. It is a norepinephrine-dopamine reuptake inhibitor. It is also a nicotinic acetylcholine receptor antagonist. Treatment of Hypoactive Sexual Desire Disorder (HSDD) in women.

(1-Pentylindol-3-yl)-(2,2,3,3-tetramethylcyclopropyl)methanone (KM X-1, UR-144) Novel cannabinoid

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Diazepam (Valium) is a benzodiazepine drug.Diazepam binds to a specific subunit on the GABAA receptor at a site distinct from the binding site of the endogenous GABA molecule, known as an allosteric site. Diazepam is also a PDE4 inhibitor: