Borghese Chapel and Salus Populi Romani in the Basilica of St. Mary Major Salus Populi Romani, or Health of the Roman People due to a miracle in which the icon helped keep plague from the city is perhaps the oldest Marian image in Rome, Italy. The icon is at least a thousand years old, and according to a tradition was painted from life by St Luke the Evangelist using the wooden table of the Holy Family in Nazareth.
A detail of an 18th century copy of the icon of the Salus Populi Romani (Protectress of the Roman People). The original painting is kept in the archbasilica of Santa Maria Maggiore in Rome. The image has since long been considered a true portrait of Mary, as according to legend it was painted by St Luke.
The Deesis Mosaic, Hagia Sophia, Istanbul | In Byzantine art, and later Eastern Orthodox art generally, the Deësis or Deisis (Greek: δέησις, "prayer" or "supplication"), is a traditional iconic representation of Christ in Majesty or Christ Pantocrator: enthroned, carrying a book, and flanked by the Virgin Mary and St. John the Baptist, and sometimes other saints and angels.