Carlos, Prince of Asturias, also known as Don Carlos (8 July 1545 – 24 July 1568), was the eldest son and heir The young Infante Carlos was delicate and deformed. As a young adult, began to show signs of mental instability. Many of his physical and psychological afflictions may have stemmed from the inbreeding. Carlos was mentally unstable and was imprisoned by his father in early 1568, dying after half a year of solitary confinement.In 1562.
Eric XIV (1533 - 1577). King of Sweden from 1560 until 1568, when he was deposed. He showed signs of mental illness near the end of his reign, which is now believed to be schizophrenia. He was imprisoned after being deposed, and most likely poisoned.