P values, the 'gold standard' of statistical validity, are not as reliable as many scientists assume. One researcher suggested rechristening the methodology “statistical hypothesis inference testing”, presumably for the acronym it would yield. Here we explain why if you think you can trust 'em, you should think again. http://www.nature.com/news/scientific-method-statistical-errors-1.14700?WT.mc_id=PIN_NatureNews Nature Publishing Group

The quantum source of space-time : Nature News & Comment

CRISPR, the disruptor : Nature News & Comment

Today is #DNAday a holiday celebrated on April 25 which is the day in 1953 when James Watson and Francis Crick published papers in Nature on the structure of DNA. Credit: Nature Publishing Group

Should we set limits on what science can probe? Are some areas too questionable to investigate? Nature explores taboo genetics - the genetics of IQ, race, sexuality and violence - and the scientists that have crossed the red line to work on them. A poll asks if you think each of these areas should be off-limits to scientists... http://www.nature.com/news/ethics-taboo-genetics-1.13858?WT.mc_id=PIN_NatureNews Nature Publishing Group

It could have been revolutionary but just a few months after it was published in Nature, a new technique that would have allowed scientists to easily discern the atomic structure of molecules is on the ropes. Does a correction and a failure to reproduce the technique in other labs spell the end for 'crystal-free crystallography'? http://www.nature.com/news/revolutionary-method-for-probing-molecular-structure-unravels-1.13798?WT.mc_id=PIN_NatureNews

Science publishing: The trouble with retractions : Nature News

Job satisfaction [among scientists]: Turbulent times : Naturejobs

Wow! Gravitational lensing - the bending of light by stars - has been reproduced on a microchip. “This is indeed the first time an exact solution of Einstein's equations was mimicked” using an optical model, says physicist Ulf Leonhardt. The simplicity of the experiment “beautifully illustrates some of the ideas of general relativity”, he adds. http://www.nature.com/news/curved-space-time-on-a-chip-1.13840?WT.mc_id=PIN_NatureNews Credit: Sheng, C.et al. Nature Publishing Group

! Nature, Volume 497 Number 7449. A three-dimensional view of intact mouse hippocampus rendered transparent, showing neurons expressing eYFP (green), parvalbumin (red) and glial fibrillary acidic protein (blue). Cover: Kwanghun Chung & Karl Deisseroth, HHMI/Stanford Univ. Nature Publishing Group

By looking at the the detailed structure of the radiation left over from the Big Bang, two cosmologists have shown that the Universe might be shaped like a saddle. If their model is correct, it would overturn the long-held belief that the cosmos is flat. http://www.nature.com/news/universe-may-be-curved-not-flat-1.13776?WT.mc_id=PIN_NatureNews CREDIT: ESA Nature Publishing Group

Supersymmetry posits that for every ordinary particle there exists a “superpartner”: From “Is Nature Supersymmetric?” by Howard E. Haber and Gordon L. Kane, in Scientific American, June 1986. Graphic by Gabor Kiss

Nature, Volume 499 Number 7457. Phages naturally coexist in abundance with their bacterial hosts in the mammalian gut. Antibiotic treatment can negatively affect the gut environment and cause immune and metabolic deficiencies. (Cover illustration: Jenn Hinkle) Nature Publishing Group

Nature, Volume 510 Number 7503. Many of the high-resolution membrane protein structures published recently are notable for the presence of lipids closely associated with the protein, prompting the question, how are these lipids influencing membrane complex structure? On the cover, IM-MS captures a native membrane protein complex emerging from an ion mobility cell. Shown is the ammonia channel in apo, one- and two-lipid bound states. Cover: Arthur Laganowsky

Nature, Volume 497 Number 7447. Genetically modified crops, we were promised, would deliver a second green revolution. In this special issue, Nature charts the development of GMO technology in the past three decades and looks for the green shoots that might form the basis of the next generation of GMOs. Cover: Kelly Krause/Nature (photo: Nagy-Bagoly Arpad/Shutterstock) Nature Publishing Group

No access to article unless you have NPG Journal access. TACKLING ANIMAL DISEASES to protect human health Veterinary vaccines might recombine to produce new virus strains. Different vaccine viruses, of European (left) and Australian (right) origin, used simultaneously to control laryngotracheitis infection in chickens, were found to have recombined to produce new infectious viruses. (Credit: Andrea Rinaldi, EMBOR) Nature Publishing Group

Leptons and Quarks (top) and three forces of nature (bottom): From “A Unified Theory of Elementary Particles and Forces” by Howard Georgi, in Scientific American, April 1981. Graphics by Gabor Kiss

Lifespans predictable at early age Worm study suggests that activity in mitochondria determines ageing.

Nature Outlook Obesity: Rates of obesity continue to rise worldwide. About 65% of Americans are either overweight or obese, resulting in 300,000 excess deaths per year. Yet surprisingly little is known about the science which underpins this global epidemic. Why do some people seem predisposed to weight gain? And how does appetite actually work? Devising an effective strategy to combat obesity will require the integration of insights from neuroscience, genetics and the behavioural sciences.

First results from psychology’s largest reproducibility test Crowd-sourced effort raises nuanced questions about what counts as replication.

Happy Darwin Day! Here’s our free special from the archives on his life, science and legacy.