Figure 12 Class IV lupus nephritis large electron-dense granular deposits around capillary loops are seen in the subepithelial space (arrows in A), the intramembranous region of the basement membrane (arrows in B) and the subendothelial space (arrows in C).
Small vessel vasculitis causing pulmonary-renal syndrome = 1. anti-GBM disease or Goodpasture's disease (triad of alveolar hemorrhage, glomerulonephritis, and anti-GBM antibodies against collagen IV, high fatality due to suffocation!) 2. ANCA disease (either c-ANCA proteinase 3 or p-ANCA myeloperoxidase 3. immune complex mediated (like SLE)- usually doesn't do this.
I was diagnosed with SLE 8 years ago at the age of 25 after my first two children were born. Since then lupus has attacked my nervous system, my heart, my liver, my ureturs, and the last few years kidney involvement. At this point my Drs are preparing me for dialysis. It's not easy, I still get mad, I still cry, but I've learned that I'm stronger than I could have imagined. I have 4 children now that need me.Lupus will NOT rob them of a mother! ~Eva